Sensitivity of prucalopride succinate in different solvents by UV method
Department Of Pharmaceutical Analysis, NRI College of Pharmacy, Pothavarappadu (V), Agiripalli (M), Andhra Pradesh, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(03), 190–196.
Article DOI: 10.30574/wjbphs.2023.13.3.0126
Publication history:
Received on 03 February 2023; revised on 22 March 2023; accepted on 25 March 2023
Abstract:
Prucalopride succinate is a selective serotinin 5-HT4 receptor agonist. Two simple UV spectrophotometric methods have been developed for the estimation of Prucalopride succinate in bulk and pharmaceutical formulations. The absorption maxima (λmax) of prucalopride succinate was found to be 226 nm in 0.1N HCL and Phosphate buffer (PH-2.0) respectively and Beer-Lambert’s law was obeyed over the concentration range 2- 16µg/ml. LOD and LOQ values of prucalopride succinate was found to be 0.0105 µg/ml, 0.03465 µg/ml and 0.0143 µg/ml, 0.04719 µg/ml in 0.1N HCL and Phosphate buffer respectively. The validation parameters were treated statistically with ‘t’ test and significant differences were observed. The study clearly revealed that the solvents influence the determination of Prucalopride succinate. The methods developed were rapid and easy can be applied for the estimation of Prucalopride succinate in bulk and pharmaceutical formulations.
Keywords:
Prucalopride succinate; Hydrochloric acid; Phosphate buffer; UV spectrophotometry
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