Stigma -5, 22, -Diene-3-O-Beta-D-Glucopyranoside: A new antimicrobial glycoside from Tetrapleura tetraptera
1 Chemistry Advanced Research Centre, Sheda Science and Technology Complex (SHESTCO), Abuja- Nigeria.
2 Natural Products Research Group, Department of Chemistry, University of Kwazulu Natal, Durban- South Africa.
3 Department of Chemistry, University of Abuja, Abuja- Nigeria.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2020, 04(03), 021-042.
Article DOI: 10.30574/wjbphs.2020.4.3.0066
Publication history:
Received on 08 September 2020; revised on 25 November 2020; accepted on 28 November 2020
Abstract:
Indigenous medical practices have been the subject of much attention in the literature of various disciplines to date but the specificity, mode of action and clinical efficacy of most traditional plants have not been established in a manner consistent with standards of modern pharmacognosy and pharmacology. In order to find antimicrobial lead compounds and to provide scientific validation for the use of Tetrapleura tetraptera (Schum.& Thonn.) in traditional medicine . Extensive chromatographic separation of stem bark and leaf extracts led to the isolation of three distinct compounds. Anti-microbial spectrum of these obtained compounds revealed that stigma-5, 22, - diene-3-O-β-D-glucopyranoside showed activity against Staphylococcus aureus (32 mm), Streptococcus pyrogenes (30 mm) and Candida tropicalis (30 mm). It is therefore recommended for further work for a possible development of new drugs.
Keywords:
Antimicrobial; Zone of inhibition; Isolates; Tetrapleura tetraptera; Glucopyranoside.
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