Study on correlation between Vitamin D status and proinflammatory cytokines in children with RSV bronchiolitis
1 Department of Pediatrics, Faculty of Medicine, Medical University Pleven, Pleven 5800, Bulgaria.
2 University Hospital Dr. Georgi Stranski, Pleven 5800, Bulgaria.
3 Department of Social Medicine and Health Management, Faculty of Public Health, Medical University Pleven, Pleven 5800, Bulgaria.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 20(02), 321–329.
Article DOI: 10.30574/wjbphs.2024.20.2.0882
Publication history:
Received on 30 September 2024; revised on 10 November 2024; accepted on 12 November 2024
Abstract:
The objective of our study was to evaluate vitamin D status and serum levels of C-reactive protein (CRP) alongside the proinflammatory cytokines IL-1β, IL-6, and TNF-α, in order to investigate their correlation with the incidence and severity of acute RSV bronchiolitis in children. The study included 39 children, aged 1 month to 2 years, divided into two subgroups: children with acute RSV bronchiolitis (n=20) and a control group of healthy children (n=19). No significant difference in vitamin D status was found between the patient and control groups. The patient group exhibited elevated levels of IL-1β and TNF-α compared to healthy children, while IL-6 levels did not differ significantly between the two groups. Correlation analysis demonstrated a positive, statistically significant association between IL-6 and TNF-α. However, no statistically significant correlations were observed between the severity of broncho obstructive syndrome and other indicators, including 25(OH)D, parathyroid hormone (PTH), IL-1β, IL-6, TNF-α, and CRP. Furthermore, no correlation was found between vitamin D levels and any of the cytokines. These findings suggest that while inflammatory markers may play a role in RSV bronchiolitis, vitamin D status does not appear to be a contributing factor to the incidence or severity of the disease in the pediatric population studied.
Keywords:
RSV; Bronchiolitis; Vitamin D; Proinflammatory cytokines
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