Synthesis, characterization and in vitro anti mycobacterial activity of some novel benzothiazole derivatives
1 Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna nagar, Guntur-522510, Andhra Pradesh, India.
2 Department of Pharmaceutical Chemistry, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil-626126, Tamil Nadu, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2022, 12(01), 114–121.
Article DOI: 10.30574/wjbphs.2022.12.1.0153
Publication history:
Received on 06 September 2022; revised on 14 October 2022; accepted on 16 October 2022
Abstract:
World Health Organization considers Mycobacterium tuberculosis is the most dangerous chronic transmittable disease. Development of resistance by Mycobacterium tuberculosis is a common problem world Wide. To combat these problems there could be a solution that we should search newer molecules with different mechanism of action to fight against such diseases. A series of some novel benzothiazole derivatives (I-X) have been synthesized and evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using Microplate Alamar Blue Assay Method (MABA). Structures of the synthesized compounds were supported by means of IR, NMR and MASS spectral studies. Among the synthesized compounds, compound [IX], 2-[5-(4-Bromophenyl)-2-furylcarboxamido]-6-methoxy-l,3-benzothiazole exhibited a significant activity when compared with the standard drug Isoniazid. This could be the remarkable starting point to develop new lead molecules with potential antitubercular activity.
Keywords:
Mycobacterium tuberculosis H37Rv; Benzothiazole; Antitubercular activity; Isoniazid; MABA
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