Systematic review: How to obtain Fibrinolytic Enzymes from Fungi
1 Banjarmasin Blood Transfusion Services Indonesian Red Cross Jl.S.Parman No.14, Banjarmasin, South of Kalimantan.
2 Central Blood Transfusion Services Indonesian Red Cross, Jl.Joe No.7 Lenteng Agung, South of Jakarta.
3 Research Centre for Vaccine and Drug, National research and Innovation Agency, Cibinong Science Centre, Jl.Raya Bogor, Bogor, West Java.
4 Master’s Program in Biomedical Sciences Faculty of Medicine University of Indonesia, Jl. Salemba Raya No. 6, Central of Jakarta.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 18(02), 394–402.
Article DOI: 10.30574/wjbphs.2024.18.2.0303
Publication history:
Received on 12 April 2024 revised on 20 May 2024; accepted on 22 May 2024
Abstract:
Fibrinolytic complications such as stroke and peripheral occlusive disease due to vascular occlusion are significant causes of poor prognosis and death. Given the ability of mushroom fibrinolytic enzymes to dissolve blood clots and prevent side effects, their use as a potential thrombolytic therapy has attracted great interest. Serine protease, metalloprotease, and serine metalloprotease are protease enzymes that can affect the fibrinolytic mechanism by dissolving blood clots and increasing blood flow. This systematic review aimed to disclose all information regarding the production, purification, and characterization of fibrinolytic proteases from fungi. Searches were conducted on online media databases, including Google and journal sites (NCBI, PubMed, and others, using the keywords "(Fibrinolytic Enzymes) OR (Fibrinolytic Proteases) AND (Fungi or Mushrooms)" from 2012-2023. This systematic review observed reviews from the purification and characterization steps, indicating the need for attention to the manufacturing process and enzymatic applications. The production of these enzymes by fungi is associated with developments in pharmaceutical applications.
Keywords:
Enzymes; Fibrinolytic; Fungi; Purification; Characterization
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