Therapeutic potential of the MSC secretome
Department of Biotechnology, RV College of Engineering, Bengaluru, Karnataka, India – 560059.
Review
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(03), 001–005.
Article DOI: 10.30574/wjbphs.2023.15.3.0368
Publication history:
Received on 20 July 2023; revised on 31 August 2023; accepted on 03 September 2023
Abstract:
In the last two decades, MSCs have gained substantial attention as a potential source for regenerative therapy. This is due to several reasons such as the ability to isolate using non-invasive techniques, the cell’s ability to divide into several lineages including those of non-mesodermal origin and the absence of HLA-DR on the surface of the cell. However, immune rejection is still a possibility in the case of MSC transplant and several studies have reported low survivability of these cells in the transplanted tissue. A remedy to this is the use of the MSC secretome which contains molecules released by the cells for immunomodulation and other regulatory behaviours. Interest in the secretome has been increasing with several studies reporting similar regenerative potential when compared to the cells themselves. This review contains a brief account of the therapeutic effects of the MSC secretome in the case of bone, musclular & neural regeneration.
Keywords:
MSCs; Secretome; Exosomes; Extracellular Vesicles; Regenerative Therapy
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0