Verification of the analytical performance of the serum gamma-glutamyl transferase assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda

Loubna Yacoubi 1, 2, *, Zainab Kajeiou 1, 2, Sabah Mokhtari 1, 2, Issam mokhtari 1, 2, Salwa Dahmani 1, 2, Nisma Douzi 1, 2, El-houcine Sebbar 1, 2 and Mohammed Choukri 1, 2

1 Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.
2 Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Morocco.
 
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(02), 098–103
Article DOI: 10.30574/wjbphs.2023.15.2.0349
Publication history: 
Received on 30 June 2023; revised on 07 August 2023; accepted on 10 August 2023
 
Abstract: 
Introduction: As part of our study, we set out to evaluate the analytical performance of the gamma-glutamyl transferase (GGT) assay using an Abbott kit on the Alinity ci® automated system in the biochemistry laboratory of the CHU Mohammed VI in Oujda.
Materials and methods: This study assessed the repeatability and reproducibility of Alinity ci® and compared the results obtained by the Alinity ci® and Architect ci-8200® automated systems.
Results: The results obtained met the acceptability criteria recommended by the supplier and the Valtec protocol of the Société Française de Biologie Clinique (SFBC), demonstrating overall satisfaction with the study. The Alinity ci® automated system demonstrated the analytical performance required for accurate and reliable determination of GGT levels.
Discussion: Validation of an analytical method is an essential step in guaranteeing that the result obtained is as close as possible to the reference value of a sample. Several standards and technical guides set out requirements for the performance criteria of an analytical method, notably NF EN ISO 15 189.
Conclusion: the verification study of the GGT assay method produced satisfactory results, providing a high level of reliability for analysis results from the central laboratory of the CHU Mohammed VI d'Ouja. This work forms an essential basis for developing an accreditation procedure, which is part of the quality approach to which our laboratory is committed.
 
Keywords: 
Gamma-glutamyl transferase; Verification; Repeatability; Reproducibility; Alinity ci®
 
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Copyright information: 
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0