The vitamin- D quantity versus bone quality: A logistic based regression modeling in Jordanian cohort who at higher risk of osteoporotic fracture
1 Clinical Pharmacy at the Clinical Pharmacy department; King Hussein Medical Center, Royal Medical Services; Amman, Jordan.
2 Logistic Pharmacy at the Logistic Pharmacy department; King Hussein Medical Center, Royal Medical Services, Amman, Jordan.
3 Rehabilitation and Rheumatology; Rheumatologist department; King Hussein Medical Center, Royal Medical Services; Amman, Jordan.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(02), 263–269.
Article DOI: 10.30574/wjbphs.2023.15.2.0352
Publication history:
Received on 02 July 2023; revised on 20 August 2023; accepted on 23 August 2023
Abstract:
Background: Several studies validated the positive impacts of Cholecalciferol derivatives; including dietary and non-dietary sources, on the bone architectural contents and the overall skeleton densities. We primarily aimed in this study to explore the optimal thresholds for the studied patients’ 25-OH Cholecalciferol levels that are correlated with the higher probabilities for having lumbar bone mineral density (LBMD) exceeding 0.835 g per cm2 and femoral hip bone mineral density (fH_BMD) exceeding 0.755 g per cm2.
Methods: An observational retrospective study was conducted for patients, who are at risk of osteoporotic fracture, Firstly, a Binary Logistic Regression analysis was separately conducted for the investigated patients’ vitamin D levels against the patients’ fH_BMD ≥0.755 (Positive state) vs <0.755 (Negative state) and against the patients’ LBMD≥ 0.835 (Positive state) vs <0.835 (Negative state). Both the Receiver Operating Characteristic and the Sensitivity analyses were thereafter be conducted and the performances indices were explored.
Results: Our constructed BLgR models, that logistically integrated the binary correlation between the investigated patients’ Vit D levels and their femoral hip or lumbar bone mineral densities, respectively, were constructed as [= e (--1.455+0.109× Vit D) /1+ e (--1.455+0.109× Vit D)] or [= e (--22.127+0.829× Vit D) /1+ e (--22.127+0.829× Vit D)], respectively.
Conclusion: The optimal Vitamin D levels for our investigated Jordanian cohort to have a higher probability of lumber and femoral hip bone mineral; densities were identified at 27.05 ng/ml and 27.25 ng/ml, respectively.
Keywords:
Vitamin D levels; 25-hydroxy Cholecalciferol; Binary Logistic Regression; Bone mineral density; Osteoporotic fracture; Jordanian cohort
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