Vitamin D: Structure and mechanism of action
Department of Biochemistry, Azerbaijan Medical University, Baku, Azerbaijan.
Review
World Journal of Biology Pharmacy and Health Sciences, 2022, 09(03), 036–041.
Article DOI: 10.30574/wjbphs.2022.9.3.0052
Publication history:
Received on 02 February 2022; revised on 10 March 2022; accepted on 12 March 2022
Abstract:
Vitamin D has received more attention in recent years as a result of the resurgence of vitamin D deficiency and rickets as a global health issue, as well as compelling evidence in the laboratory indicating that 1,25-dihydroxy vitamin D3 [1,25(OH)2D3], the hormonally active form of vitamin D, generates several extraskeletal biological responses such as inhibition of breast, colon, and prostate cancer cell progression; effects on the cardiovascular system; and protects against. This review covers our present knowledge of vitamin D and its bioactivation, as well as fresh findings that have altered our understanding of vitamin D activity in both classical and nonclassical target tissues. This page also assesses vitamin D's alleged involvement in extraskeletal health, provides an overview of 1,25(OH)2D3 analogs that have been created, and highlights unanswered problems.
Keywords:
Vitamin D; Structure; Metabolism; Cholecalciferol
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