In vitro anticancer activity of Astaxanthin

Uma Nath U 1, *, Ravi. R 2, Sundara Ganapathy 3 and Lal Prasanth 4

1 MGM Silver Jubilee College of Pharmacy, Kilimanoor Trivandrum, Kerala, India.
2 Department of Pharmaceutical Chemistry, SB College of Phamacy, Sivakasi, India.
3 Karpagam University, Karpagam Academy of Higher Education, Pollachi main Road, Eachanari Post, Coimbatore 641021, India.
4 Department of pharmaceutical Chemistry, Wyanad Institute of Medical Science, Wyanad, Kerala, India.
 
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2021, 05(03), 033-037.
Article DOI: 10.30574/wjbphs.2021.5.3.0110
Publication history: 
Received on 23 December 2020; revised on 02 January 2021; accepted on 04 January 2021
 
Abstract: 
This study was designed to determine the in vitro anticancer potential of the Astaxanthin isolated from shrimp shell waste (ETC) against Ehrlich Ascites Carcinoma (EAC) induced cancer in swiss albino mice. The anticancer activity was assessed using in vitro cytotoxicAity, mean survival time, tumor volume and hematological studies. The reliable criteria for evaluating the potential of any anticancer agent is the prolongation of lifespan of the animal and decrease in WBC count of blood. The high dose of ETC (200 mg/kg, orally) significantly reduced the tumor growth which was demonstrated by increased lifespan of the mice and restoration of hematological parameters. ETC was also found to be cytotoxic in the in vitro parameter which shows that ETC possesses significant anticancer potential.
 
Keywords: 
Cancer; Astaxanthin; Cytotoxicity; Shrimp
 
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