Von Willebrand disease in a neonate: A case report
Department of neonatology, Children's hospital of Rabat, Morocco. Faculty of medicine and pharmacy, University Mohammed V, Rabat, Morocco.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 14(01), 135–137.
Article DOI: 10.30574/wjbphs.2023.14.1.0185
Publication history:
Received on 08 March 2023; revised on 15 April 2023; accepted on 18 April 2023
Abstract:
Von Willebrand disease (VWD) is a constitutional bleeding disorder of autosomal inheritance characterized by a quantitative or functional abnormality of the factor Willebrand. We report the observation of a neonate with a confirmed diagnosis of von Willebrand disease in the neonatal period.
This disease is a very heterogeneous clinically, phenotypically and genetically, and poses a diagnostic difficulty. The biological diagnosis is based on first-line tests (prothrombin level and activated partial thromboplastin time) completed by the measurement of the coagulant activity of factors VIII, IX and XI, as well as the activity and antigen of Von Willebrand factor (VWF). The treatment strategy for VWD should be considered in collaboration with a hematologist aiming to correcting VWF and factor VIII levels. Therefore, a recombinant VWF concentrate has recently been introduced and has proven to be effective.
Keywords:
Coagulation; Hemorrhage; Hemostasis; Platelets.
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0