Ocuserts: A novel ocular-drug delivery method: An update
1 Lala Lajpat Rai College of Pharmacy, PS Sadar, Moga, Punjab 142001, India.
2 Amritsar Group of Colleges, Pharmacy department, 12 KM stone, Amritsar Jalandhar GT Road Amritsar 143001, India.
3 Khalsa College of Pharmacy GT road Amritsar, Punjab 143002, India.
4 Katyayani college of education meerut-Karnal Highway, Meerut, Uttar Pradesh 250241, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(01), 470–477.
Article DOI: 10.30574/wjbphs.2023.13.1.0025
Publication history:
Received on 03 December 2022; revised on 14 January 2023; accepted on 17 January 2023
Abstract:
Ocuserts are sterile ocular preparations that may follow a controlled release technique to extend medication residence duration and reduce nasolacrimal discharge. The goal of the ocuserts is to improve medication contact with conjunctiva tissue to sustain consistent dosage release. Uniform ocular medication levels decrease systemic side effects, minimizes dose, boosting patient compliance. Ocuserts are prepared by solvent casting, glass substrate, and melt extrusion technique. Modified ocuserts may be used to obtain desired medication concentration for a given time at the site of action. Extended corneal contact duration is the major success in ocular medication delivery. Non-conventional approaches like liposome, microsphere, prodrug, etc. may improve ocular drug delivery systems and reduce side effects. Diffusion, osmosis, or bioerosion are the various methods that govern drug release from ocusert.
Keywords:
Ocuserts; Eye; Ophthalmic preparation; Conjunctiva; Corneal contact
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