Mortality predictors in emergency department adult patients with sepsis: A systematic review

Background: Sepsis was regarded as a major global public health concern; it continues to be associated with a high death rate despite advancements in contemporary treatment. This research aims to evaluate the predictive effect of clinical scoring systems and biomarkers for sepsis patients in ED.
Method: In accordance with PRISMA principles, we carried out this systematic review. We used the internet databases MEDLINE, Google Scholar, and EMBASE to conduct a thorough search of the literature. Articles written in English and released between 2015 and 2023 were involved in the search. Using predictors and ED, we first conducted a comprehensive search that included sepsis and infectious illnesses.
Result: A total of 3029 patients from 7 publications—3 cohort, 2 observational, and 2 case control studies—were included in this study. The study by Song et al. in 2019 had the highest fatality rate (46.6%), while the study by Duplessis et al. in 2018 had the lowest mortality rate (6.4%). SIRS criteria, qSOFA score, International Sepsis Conference 2001, and American College of Chest Physicians Guidelines are the diagnostic criteria that are employed. AUC varied from 33.7 (MMP9) to 0.89 (IL-6).
Conclusion: AUC was increased significantly when CSSs were combined with IgE, presepsin, IL-6 and PCT.