The application of Pennes’ bioheat equation to determine the effect of temperature on drug diffusion
Department of Mathematics and Statistics and, MMDARG, Federal University Otuoke, Nigeria.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(03), 001–011.
Article DOI: 10.30574/wjbphs.2023.13.3.0115
Publication history:
Received on 21 January 2023; revised on 01 March 2023; accepted on 03 March 2023
Abstract:
In this work, we discuss how temperature (internal heat) affects medication distribution between the stomach and circulatory compartments. The study shows that the behavior of medication distribution is related to high or low temperatures in the compartments under examination (the stomach and bloodstream). Here, we attempted to comprehend the behavior of a medicine supplied to the body over time by solving the models set up to mimic the system. The model (a system of ODEs) was solved both analytically and computationally using Wolfram Mathematica. The results reveal that as the temperature increases, the medication delivered into the system diffuses quicker between the compartments, and as the temperature decreases, the medication diffuses slower, demonstrating the peculiarity of this study effort.
Keywords:
Mathematical Models; Pharmacokinetics; Pennes’ Bio-heat Equation; Drug Distribution; Ordinary Differential Equations; Temperature; Drug Diffusion
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0