Oxidation of threonine by Corey’s reagent: A kinetic study

Oxidation of Threonine by pyridinium chlorochromate in DMF-water medium has been studied. The rate of reaction was found to be of first order dependence on [PCC], [Threonine] and [H+]. The Michaelis–Menten type kinetics is observed with respect to Threonine. The increase in the rate of oxidation with increase in acidity indicates the involvement of a protonated chromium (VI) species in the rate-determining step. The product of oxidation has been identified as an aldehyde. The rate of reaction decreased with increase in the polarity of medium indicates that there is involvement of an ion-dipole type of interaction in the rate-determining step.