The complicated adverse effect relating to the used of direct herbal traditional extract(medicine) arbitrary in reciprocal to the use of modified herbal syrup containing antioxidants/nutraceuticals supplements (polyherbal drugs/syrup) as an active antiagi

Genetic(Pathogenic microbial free radical), lifestyle (social engagement) and environmental(free radical) are becoming unfathomable nowadays. Thus the rapid socio-economical development in recent decades, the proportion of elderly has rapidly, geometrically and arithmetically increased worldwide. In addition, many aging -related diseases have shown an upward trend, including nervous system disease, cardiovascular diseases, metabolic diseases, cancer diseases, covid-19 viral suppression infections, HIV/AID viral suppression infections etc., respectively. The burden of aging related disease has become an urgent global health wise challenge; thus, which would have been tackle with immediate alacrity for permanent solution. Although therapies involving these agents have shown promising potential with the efficacy of a good number of herbal products clearly established, many of them remain untested and their use are either poorly monitored or not even monitored at all. The consequence of this is an inadequate knowledge of their mode of action, potential adverse reactions, contraindications, and interactions with existing orthodox pharmaceuticals and functional foods to promote both safe and rational use of these agents. Since safety continues to be a major issue with the use of herbal remedies, it becomes imperative, therefore, that relevant regulatory authorities put in place appropriate measures to protect public. Selected ingredients of these dietary supplements include several vitamins, mineral, phytochemicals, complex of amino acid residues(proteins), probiotics, vitamins A, B, C, D and E assist in maintaining skin veracity. Zinc, Copper, and Selenium are the main minerals which are involve in sustenance of healthy skin. Phytochemical consisting of flavonoid, terpenoid, and alkaloids with antibacterial, antifungal, antioxidative property may benefit the texture and physiological parameters of skin delay.. In view of his review, it talks about results, discussions,toxicity-related issues and major safety concerns arising from the use of herbal medicinal products and also highlights some important challenges associated with effective monitoring of their bio-safety