Verification of the analytical performance of the serum total cholesterol assay on Abbott Architect ci8200
1 Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Morocco.
2 Central Laboratory, Mohammed VI University Hospital of Oujda, Morocco.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(02), 104–113.
Article DOI: 10.30574/wjbphs.2023.15.2.0326
Publication history:
Received on 26 June 2023; revised on 05 August 2023; accepted on 07 August 2023
Abstract:
Serum total cholesterol measurement is an essential aspect of preventive healthcare as high levels of cholesterol are linked to various diseases such as atherosclerosis, heart attacks, and strokes. Serum cholesterol measurement is a simple blood test that assesses the levels of cholesterol in the bloodstream. It is an important diagnostic tool that helps healthcare professionals evaluate a patient's risk of developing cardiovascular disease and make decisions regarding treatment and lifestyle changes.
Our study aims to verify the analytical performance of the serum total cholesterol assay method using an Abbott kit on the Architect ci8200 automated system in the biochemistry laboratory of the Mohammed VI University Hospital of Oujda. The analytical performance of the kit was verified through flexible scope A by performing a performance study on the Architect ci8200. We evaluated the repeatability, the reproducibility, the imprecision of the measurements and the comparison between two Architect ci8200 automatons. All the results obtained are in conformity with the acceptability criteria recommended by the supplier and the Valtec protocol of the ‘Société Française de Biologie Clinique’ (SFBC), and the study is globally satisfactory.
The analytical performance of the Architect ci8200 automated system was satisfactory for a reliable determination of total cholesterol. Verification of methods of dosage in the medical laboratory is crucial to ensure the accuracy, precision, and reliability of laboratory test results. Verification involves confirming that the test method employed is appropriate for the intended use, produces results that are consistent with the claimed performance characteristics, and meets the laboratory's quality control and quality assurance requirements.
Keywords:
Total cholesterol; Verification; Quality; Architect ci 8200; Repeatability; Reproducibility
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0