A causal relationship between diabetes mellitus and depression

In today’s modern world depression has become a common stress factor among both men and women irrespective of age. But to be specific, it has been found that there is a strong relationship between diabetes and depression. The rate of this relationship seems to be higher and much literature suggests us the numbers could be increasing in the future. Depression in diabetes may arise due to some factors such as comorbidities, improper management of blood glucose level, patient’s financial status in managing the conditions can precipitate depression. Other physiological factors like the increased sympathetic nervous system, HPA-axis, and increased cortisol in the brain can contribute to the development of diabetes and depression.  This comorbid condition of depression and diabetes decreases the quality of life.  On the other hand, people with depression have a high incidence of developing diabetes. Depression has been a significant risk factor in developing diabetes, especially T2DM. Several neuroendocrine and neurotransmitter disorders are found along with depression and diabetes this closely relates and explains the relationship between the two conditions. Insulin resistance a specific risk factor was found to correlate depression and diabetes. Antidiabetic drug, thiazolidinedione was found to lessen the effect of both depressive disorder and insulin resistance in individuals experiencing diabetes and depression.