Formulation and evaluation of valsartan solid dispersion for improvement of dissolution profile

In terms of physicochemical factors, solubility is the most crucial to medication absorption and therapeutic efficacy. Bioavailability is low because the medicine is poorly soluble in water and is absorbed poorly in aqueous GIT fluid. In this research, a solid dispersion version of the hypertension drug valsartan was developed to improve its bioavailability and blood pressure-lowering effects. The solubility of Valsartan is improved by using the solid dispersion (kneading method) technique using Soluplus as a carrier (also act as taste masking agent). They were distinguished from one another based on studies examining solubility, in vitro dissolution, dissolving efficiency, and stability. X-ray diffraction, FT-IR spectroscopy, and differential scanning Calorimetry were used to investigate the solid state properties of dispersions (XRD). A 1:1 medication-to-polymer solid dispersion showed 97.77% drug release after 30 minutes. FTIR, DSC, and XRD analyses of solid dispersions all corroborated their formation. A DSC study shown that under accelerated climate settings, kneaded solid dispersion remained stable for 30 days longer than other solid dispersions.