In vitro studies of magnesium oxide nano-particles of Saccharum officinarum root extract: Evaluation of the antidiabetic effect using alpha-glucosidase enzyme
Department of Science Laboratory Technology, Federal Polytechnic Ilaro, P.M.B 50, Ilaro, Ogun State, Nigeria.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 16(01), 117–122.
Article DOI: 10.30574/wjbphs.2023.16.1.0357
Publication history:
Received on 08 July 2023; revised on 22 August 2023; accepted on 25 August 2023
Abstract:
Objective: Magnesium oxide nanoparticle green synthesis is said to have a wide range of biomedical uses. Inhibiting the activity of pancreatic enzymes is one method for treating diabetes. The goal of this study was to show in-vitro evidence that Saccharum officinarum magnesium oxide nanoparticles may inhibit the activity of the enzyme α-glucosidase. This study had a therapeutic focus as this could be emerging candidates of new drugs for controlling hyperglycemia.
Materials and Procedures: Saccharum officinarum root extract was used to create magnesium oxide nanoparticles, which were then examined for bioactive components and tested for α-glucosidase inhibition. When the enzyme substrate solution was incubated with various doses of the grass-root Magnesium oxide nanoparticles, the activity of the enzyme was monitored to identify the kind of inhibition.
Result: Magnesium oxide nanoparticles synthesized from Saccharum officinarum root extract showed concentration and time-dependent inhibition of α-glucosidase. An 85% inhibition was observed with 0.6 mg/ml of the synthesized nanoparticles.
Conclusion: The results showed that the ethanolic extract of MgO nanoparticles synthesized by Saccharum officinarum exhibited effective antidiabetic activity, supporting its use in the treatment and control of diabetes.
Keywords:
α-glucosidase; Magnesium Oxide; Inhibition; Diabetes; Synthesis; Nanoparticles
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