Microwave induced synthesis of 4-hydroxy-3-methyl-7, 8-dihydroquinoline-5(6H)-one using proline catalyst
1 Shri Jagdishprasad Jhabarmal Tibrewala University, Rajasthan, India.
2 Sinhgad College of Science, Maharashtra, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 17(01), 114–116.
Article DOI: 10.30574/wjbphs.2024.17.1.0018
Publication history:
Received on 05 December 2023; revised on 17 January 2024; accepted on 20 January 2024
Abstract:
In the present investigation synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione using microwave heating using proline catalyst. The synthesis of Hexa-Hydro-Quinolone derivatives, carried out by sequential in situ, Michael Addition, Cyclisation, and Aromatization. A new protocol for one step synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione with 98% yield.
Keywords:
Microwave reactions; Michael addition reaction; Quinolone; Proline
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