Optimizing neurological treatments with nasal drug delivery systems
Department of Pharmacology, Jayamukhi College of Pharmacy, Narsampet, Warangal-506332, Telangana, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(01), 142–148.
Article DOI: 10.30574/wjbphs.2024.19.1.0385
Publication history:
Received on 20 May 2024; revised on 29 June 2024; accepted on 02 July 2024
Abstract:
The treatment of neurodegenerative diseases and central nervous system disorders is challenging due to the blood-brain barrier (BBB), which restricts the penetration of therapeutic molecules to the brain. Nasal Drug delivery system leverages the unique anatomy of the nasal cavity, allowing for direct access to the brain, bypassing the blood-brain barrier. This, combined with hepatic metabolism and drug elimination, reduces treatment efficacy, requires high doses, and often induces side effects. Nose-to-brain drug delivery bypasses the BBB, increasing drug concentration in the brain. The present review highlights the Mechanisms of Nasal Drug Delivery to the Brain, Advantages and disadvantages of Nasal Drug Delivery to the Brain, Nasal Drug Delivery Devices and recent studies on nose-to-brain drug delivery
Keywords:
Nasal delivery; Brain-targeting; Neurogenerative disorders; CNS disorders
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0