1 Tashkent State Medical University, Tashkent, Uzbekistan
2 Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, bUzbekistan.
World Journal of Biology Pharmacy and Health Sciences, 2026, 26(02), 313–316
Article DOI: 10.30574/wjbphs.2026.26.2.0276
Received on 07 April 2026; revised on 22 May 2026; accepted on 25 May 2026
Objective: To assess primary hemostasis disorders in patients with stable angina pectoris (SAP) and type 2 diabetes mellitus (T2DM).
Materials and Methods: A total of 112 patients with SAP were examined: SAP+T2DM (n=56) and SAP without T2DM (n=56). Platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), hs-CRP, HbA1c, and ADP-induced platelet aggregation were evaluated.
Results: The groups were comparable in age (62.1±8.7 years); 46% were women. In the SAP+T2DM group, HbA1c was 7.8±1.1% vs 5.6±0.4% (p<0.001), and hs-CRP was 3.9 (2.1–6.2) vs 2.3 (1.2–3.8) mg/L (p=0.002). MPV was 10.9±1.0 vs 10.1±0.9 fL (p<0.001), PDW was 13.6±2.1 vs 12.3±1.8% (p=0.001), and ADP-induced aggregation was 63±12 vs 54±11% (p<0.001). MPV ≥10.5 fL was associated with high platelet aggregation (OR 2.6; 95% CI 1.3–5.3).
Conclusion: T2DM in SAP is associated with a proaggregatory platelet phenotype and enhanced primary hemostasis.
Stable Angina Pectoris; Type 2 Diabetes Mellitus; Primary Hemostasis; Platelets; Aggregation; MPV.
Get Your e Certificate of Publication using below link
Preview Article PDF
Abdullaev A.Kh and Imankulova D.A. Changes in primary hemostasis in patients with angina and diabetes mellitus. World Journal of Biology Pharmacy and Health Sciences, 2026, 26(02), 313–316. Article DOI: https://doi.org/10.30574/wjbphs.2026.26.2.0276