Antitussive effects of Musanga cecropioides in animal models
1 Department of Biological Sciences, Edo State University Uzairue, Edo State, Nigeria.
2 Department of Plant Biology and Biotechnology, University of Benin, Benin City Edo State, Nigeria.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(02), 001–009
Article DOI: 10.30574/wjbphs.2024.19.2.0478
Publication history:
Received on 20 June 2024; revised on 27 July 2024; accepted on 30 July 2024
Abstract:
This study investigates the antitussive effects of Musanga cecropioides, a traditional medicinal plant, using animal models. Musanga cecropioides extracts were prepared from the leaves, roots, and root sap, and their effects were evaluated on mucus expectoration and citric acid-induced cough in mice and guinea pigs, respectively. The results indicated that aqueous and methanol extracts of Musanga cecropioides leaves and roots significantly increased mucus secretion and reduced cough frequency, with the highest effectiveness observed in methanol root extract at 100 mg/kg. These findings suggest that Musanga cecropioides possesses promising antitussive properties, supporting its traditional use in treating cough and respiratory ailments. This natural remedy could offer a safer alternative to conventional cough suppressants, warranting further clinical studies to confirm its efficacy and safety in humans.
Keywords:
Antitussive; Expectorant; Musanga cecropioides; Cough suppression; Traditional medicine
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