Effect of capacitive radiofrequency on adipose tissue of the abdominal region

Maria Clara Fonseca Costa 1, Gabriela Laguna Monaretti 1, Lenaldo Blanco Rocha 2, Mariana Molinar Mauad Cintra 2, Marco Túlio Rodrigues da Cunha 3, Nanci Mendes Pinheiro 4, Andreia Noites 5 and Adriana Clemente Mendonça 6, *

1 Graduation in Physiotherapy, Federal University of Triângulo Mineiro, Uberaba, Brazil.
2 Department of Pathology, Genetics and Evolution, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, Brazil.
3 Department of Surgical Clinic, Institute of Health Sciences, Federal University of Triângulo Mineiro, Uberaba, Brazil.
4 Department of Physiotherapy - Faculty of Human Talents, Uberaba, Brazil.
5 Department of Physiotherapy, Activity and Human Movement Study Centre, School of Allied Health Technologies, Polytechnic Institute of Porto, Porto, Portugal.
6 Department of Applied Physiotherapy, Institute of Health Sciences, Federal University of Triângulo Mineiro, Uberaba, Brazil.
 
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(02), 432–440.
Article DOI: 10.30574/wjbphs.2024.19.2.0475
Publication history: 
Received on 22 June 2024; revised on 28 July 2024; accepted on 31 July 2024
 
Abstract: 
Objectives: To evaluate histological changes in the adipose tissue after capacitive radiofrequency (RF) stimulation (thermotherapy).
Methods: This is a case series study (n=5). The volunteers received in the right infraumbilical abdominal region a single application of capacitive RF (BTL-6000 TR-Therapy Pro®), with a frequency of 480 to 520KHz, power of 150 W for 10 minutes (2 minutes per head area, 50mm in diameter). The epidermal temperature was above 40°C, and, the left side was used as control. After 30 days, an average, tissue sample was collected for histological analysis and stained with hematoxylin and eosin. Statistical analysis was performed using the SPSS program (version 20), with a significance level of 95%, and the adipocyte count was performed using Image J®. This study was registered with the XXXX Ethics Committee n. 3,461,688, Jul/12/19 and, the number of clinical trial registration was NCT04182542.
Results: The number of adipocytes on the treated side was 41.2 ± 2.0 per field and, in the control side was 36.6 ± 2.0 per field, with a significant difference (p=0.009), because of the size of adipocytes being smaller on the side treated.
Conclusion: Radiofrequency can lead to morphological changes in adipocytes in the abdominal region with an important reduction in their size.
 
Keywords: 
Radio Waves; Radiofrequency Therapy; Lipolysis; Adipose Tissue.
 
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