Oxidation of threonine by Corey’s reagent: A kinetic study
Department of Chemistry, Govt. P. G. College Pratapgarh, 312605, Rajasthan, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 18(03), 395–402
Article DOI: 10.30574/wjbphs.2024.18.3.0578
Publication history:
Received on 19 May 2024; revised on 26 June 2024; accepted on 29 June 2024
Abstract:
Oxidation of Threonine by pyridinium chlorochromate in DMF-water medium has been studied. The rate of reaction was found to be of first order dependence on [PCC], [Threonine] and [H+]. The Michaelis–Menten type kinetics is observed with respect to Threonine. The increase in the rate of oxidation with increase in acidity indicates the involvement of a protonated chromium (VI) species in the rate-determining step. The product of oxidation has been identified as an aldehyde. The rate of reaction decreased with increase in the polarity of medium indicates that there is involvement of an ion-dipole type of interaction in the rate-determining step.
Keywords:
Kinetics; oxidation; Corey’s Reagent (Pyridinium chlorochromate); Threonine; DMF (N; N-Dimethylformamide)
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