A recent ongoing effect: Hyponatremia in neurologically ill patients
Swamy Vivekanandha College Of Pharmacy, Elayampalayam - 637205, Namakkal, Tamil Nadu, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(03), 103–111.
Article DOI: 10.30574/wjbphs.2024.19.3.0600
Publication history:
Received on 28 July 2024; revised on 04 September 2024; accepted on 06 September 2024
Abstract:
Different variables altering the volume of extracellular fluid might result in hyponatremia, which is defined as a serum sodium content below 136 millimoles per liter. Depending on the volume status, it can be classified as hypovolemic, euvolemic, or hypervolemic. Hyponatremia is caused by a number of risk factors and drugs, such as diuretics, NSAIDs, and antidepressants. Hyponatremia is more common in patients with neurological conditions, especially those with head trauma, subarachnoid hemorrhage, or acute meningitis. Recent advancements in analysis for disorder of antidiuretic hormone syndrome (SIADH), a prevalent cause, include vasopressin-2 receptor antagonists. The intricate regulation of sodium and water balance by humoral, neurological, and renal mechanisms is a part of normal physiology. Hyponatremia may result from medications such as tramadol, sacubitril/valsartan, antidepressants, and anticonvulsants interfering with these mechanisms. Drug-induced hyponatremia is managed by stopping the offending agent, limiting fluid intake, and occasionally administering hypertonic saline. For chronic hyponatremia, the use of vaptans, like tolvaptan, in conjunction with urea therapy is growing. A risky complication of hyponatremia is osmotic demyelination syndrome, which can occur when the condition is treated too quickly. To avoid negative consequences, close observation and the right amount of fluids must be administered during treatment. To summarize, treating hyponatremia effectively entails determining the underlying causes, treating them, and making sure that serum sodium levels are carefully corrected to avoid consequences such as osmotic demyelination syndrome.
Keywords:
Hyponatremia; SIADH; Diuretics; hypovolemic; Euvolemic; hypervolemic; Over correction; Osmotic demylination syndrome; Drug induced hyponatremia
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