Comparative study of platelet-rich plasma in assisted reproductive technology: Impact on embryo quality and success rates

Abdelkrim Salama 1, 2, 4, 6, *, Oumnia Bouaddi 2, Razana Zegrari 2, 3, Ghyzlane EL Haddoumi 1, 2, Jamal El Yazami 4, 5, Ilham Kandoussi 1, 2 and Azeddine Ibrahimi 1

1 Medical & Pharmacy School, Mohammed V University in Rabat, Morocco.
2 Mohammed VI Center for research & innovation (CM6), Rabat, Morocco.
3 Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
4 Medically Assisted Reproduction Center, Fez, Morocco.
5 Gynecology and obstetrics practice in fez.
6 Head of MAP at MOHAMMED VI International University Hospital – Bouskoura.
 
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(03), 505–512.
Article DOI: 10.30574/wjbphs.2024.19.3.0563
Publication history: 
Received on 14 July 2024; revised on 28 August 2024; accepted on 30 August 2024
 
Abstract: 
Objective: This study aimed to evaluate the impact of female-derived platelet-rich plasma (PRP) on embryo quality and success rates in assisted reproductive techniques (ART) through a prospective randomized controlled trial, with all procedures conducted following ethical registration and approval.
Methods: We used the PRP in ART procedures with gametes and embryos. We used intracytoplasmic sperm injection (ICSI) to fertilize the eggs. We conducted a RCT comparing a group treated with PRP to a control group from the same patient. This method helped us directly assess the impact of PRP on the quality of gametes and embryos. We performed a statistical analysis using SPSS to compare fertilization rates, blastocyst formation rates, and pregnancy outcomes between the two groups.
Results: The findings suggest that PRP treatment enhances embryo quality. The PRP group demonstrated significantly higher average fertilization rates (2.80 vs. 1.93 from 3.27 used in ICSI, p = 0.004) and blastulation rates (1.60 vs. 0.73, p = 0.008), as well as superior pregnancy and implantation rates (53% vs. 27%, p = 0.027; 40% vs. 18%, p = 0.039), indicating the potential effectiveness of PRP in improving outcomes in ART.
Conclusion: PRP in ART protocols enhances embryo quality and improves pregnancy outcomes. It offers a promising option for couples undergoing medical assisted procedures
 
Keywords: 
PRP; ART; ICSI; Embryo quality; Fertilization rates; Pregnancy outcomes
 
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Copyright information: 
Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0