Geographical variations in HLA-B27 prevalence and its relationship with rheumatological disorders: A systematic review and meta-analysis
1 Students at the international faculty of Tashkent Medical Academy.
2 Department of propaedeutics of internal diseases, Tashkent Medical Academy.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 20(02), 691–695.
Article DOI: 10.30574/wjbphs.2024.20.2.0856
Publication history:
Received on 24 September 2024; revised on 13 November 2024; accepted on 16 November 2024
Abstract:
This systematic review and meta-analysis tries to examines the geographic and methodological variation in HLA-B27 prevalence and its association with rheumatological disorders such as rheumatoid arthritis or Ankylosing Spondylitis in different countries using data from seven studies in screening between 1977 and 2022, including cross-sectional, This study, as well as a prospective cohort study, reveals considerable heterogeneity in HLA-B27 prevalence Japan (78 %) found a high prevalence, which was significantly linked with ankylosing spondylitis. In contrast, lower prevalence was found in Colombia (4.5%) and France (9.6% of patients with RA), suggesting a clinically variable importance (based on our selected article). These findings highlight the influence of geographic and ethnic factors on the role of HLA-B27 in rheumatoid arthritis and highlight the need for regionally specific screening and management strategies. Future research should investigate the interactions between HLA-B27 and other genetic and environmental factors to refine diagnostic and therapeutic strategies. It is important to note that some studies were published earlier but became online available recently in years and decade.
Keywords:
HLA-B27; Prevalence; Arthritis; Ankylosing spondylitis; Reactive arthritis; Ethnic factors; Diagnostic strategies; Management
Full text article in PDF:
Copyright information:
Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0