Evaluation of cytogenetic effects induced with ciprofloxacin and metronidazole as antibacterial agents on mouse bone marrow cells in vivo
Genetics and Cytology Department, National Research Centre, Dokki, Cairo, Egypt.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2020, 02(02), 001-009.
Article DOI: 10.30574/wjbphs.2020.2.2.0022
Publication history:
Received on 09 May 2020; revised on 26 May 2020; accepted on 28 May 2020
Abstract:
Two of antibacterial agents were selected to evaluate the possibility of induction of chromosomal aberrations in mice bone marrow cells in vivo. The two agents, ciprofloxacin considered as antibacterial while metronidazole as antibacterial and antiparasitic agent. Our data revealed that both two agents ciprofloxacin (7 mg/kg b.w.) and metronidazole 30 mg/ kg b.w. induced a highly significant effect of chromosomal aberrations. We can concluded that both antimicrobial agents "metronidazole" and "Ciprofloxacin" have a marked mutagenic effects, and caution should be used in prescribing the drugs, especially in multiple courses or over long periods. The patients with severe liver disease may accumulate the drug.
Keywords:
Chromosomal aberration; Ciprofloxacin; Metronidazole; Mice; in vivo
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0