Olfactory neuroblastoma: case report and focus on cancerogenesis
1 Surgical Pathology Department, Santo Spirito Hospital, Viale Giolitti 2, 15033, Casale Monferrato (ITALY)
2 University of Eastern Piedmont Amedeo Avogadro, Viale Teresa Michel 11, Alessandria (ITALY).
Review
World Journal of Biology Pharmacy and Health Sciences, 2021, 06(03), 035–039.
Article DOI: 10.30574/wjbphs.2021.6.3.0060
Publication history:
Received on 25 April 2021; revised on 14 June 2021; accepted on 17 June 2021
Abstract:
Background: Neuroendocrine neoplasms (NENs) of the nasal cavity, paranasal sinuses and nasopharynx account for a wide spectrum of histotypes. They can range from indolent form to highly aggressive tumors. Olfactory neuroblastoma, like most sino-nasal NENs, represents a rare neoplasm that prompts diagnostic pitfalls. From a morphological perspective, olfactory neuroblastoma can mimic many nasal neoplasms but a proper recognition is mandatory for its aggressive behaviour.
Case presentation: A case of olfactory neuroblastoma in a 85 years old woman is reported. The neoplasm has been surgical removed from the nasal cavity with a clinical and radiographic diagnosis of nasal polyp. Correct diagnostic definition has needed a complete histological and immunohistochemical characterization of the tumoral tissue in surgical pathology laboratory.
Conclusion: The correct diagnosis of olfactory neuroblastoma directs the clinical management that is unique for this neoplasm in comparison to other nasal ones. Bicranial-facial surgery or a trephination procedure represent the most common approach for the treatment of this malignancy. Their success determine disease prognosis.
Keywords:
Olfactory neuroblastoma; Sinonasal-tract; Neuroendocrine neoplasm; Immunohistochemistry; Synaptofisin
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