Crossopteryx febrifuga Benth (Rubiaceae) effect of GABA concentration on brain in rats
1 Laboratory of Pharmacodynamics and Experimental Physiopathology, Faculty of Sciences and Technics, MarienNgouabi University, BP: 69 Brazzaville-Congo.
2 Laboratory of Pharmacodynamics and Experimental Physiopathology, Faculty of Sciences, Lome University.
3 Biochemistry and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, BP: 69 Brazzaville- Congo.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2022, 09(02), 040–045.
Article DOI: 10.30574/wjbphs.2022.9.2.0117
Publication history:
Received on 02 November 2021; revised on 22 December 2021; accepted on 24 December 2021
Abstract:
C. febrifuga known by the common name (Mvala) is a medicinal plant of the Rubiaceae family widely used by Congolese traditional healers to treat many diseases. For this study two extracts of aqueous and methanol were taken away with the yield of 8.5% and 11% respectively. The convulsions latency time in rats treated with different extracts was greater than 15 minutes. Among five rats one presented convulsions compared to the control group. C. febrifuga protected rats against convulsions induced by PIC and STR. Gaba dosage in rats brain homogenizing showed that C. febrifuga increased Gaba rate in rats brain (4.10 ± 0.39) compared to the control group(2.04 ± 0.03) significantly. Consequently, histamine rate decreased insignificantly.
Keywords:
Crossopteryx Febrifuga; Anticonvulsant; Rat; Histamine; Gaba
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