Enhanced oral bioavailability of baicalein using phospholipid-coated nanoparticles: A novel drug delivery system

Phospholipid-coated nanoparticle formulation of Baicalein demonstrated superior pharmacokinetic properties, including slower absorption, prolonged circulation time, and increased bioavailability compared to free Baicalein. This formulation holds significant promise for enhancing the oral bioavailability and therapeutic efficacy of Baicalein, particularly for chronic diseases where sustained drug release is beneficial. Further research should focus on the long-term safety, efficacy, and clinical applicability of this nanoparticle formulation, including evaluations in animal models and eventual clinical trials. Additionally, exploring other lipid-based nanoparticle formulations could further improve the bioavailability and therapeutic outcomes of Baicalein and similar drugs with poor solubility. Characterized phospholipid-coated nanoparticles for the delivery of Baicalein, a flavonoid with limited bioavailability. The formulation process, utilizing the emulsification technique, allowed the formation of stable nanoparticles with optimal encapsulation efficiency (88%) and drug loading capacity (6.5%). The optimization of lecithin concentration (3%) resulted in the highest encapsulation and drug loading, demonstrating the significant role of lipid concentration in the formulation of effective drug delivery systems.