1 Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60515.
2 Department of Chemistry, American University, 4400 Massachusetts Ave. NW, Washington, DC, 20016-8014, USA.
World Journal of Biology Pharmacy and Health Sciences, 2025, 24(01), 093-096
Article DOI: 10.30574/wjbphs.2025.24.1.0860
Received on 25 August 2025; revised on 05 October 2025; accepted on 07 October 2025
The focus of this study is to determine whether insulin, quorum signaling and biofilm formation are under regulation of agr and sarA regulation. Deletion strains agr-, sarA -, and agr-sarA- as well as their parent strain 8325-4 were tested with and without glucose (0.1% and 0.2%) and/or physiologic levels of insulin (2µU/mL, 20µU/mL, and 200µU/mL). In the absence of sarA and agr, there was a marked suppression of biofilm levels in the presence of insulin, indicating that insulin modulation of biofilm formation appears to be regulated, in part, by sarA and agr.
Glucose; Quorum Compound; Signaling Compound; Hormone
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Balbina J. Plotkin, Monika I. Konaklieva and Ira Sigar. Role of sarA and agr in Insulin Modulation of Staphylococcus aureus Biofilm Formation. World Journal of Biology Pharmacy and Health Sciences, 2025, 24(01), 093-096. Article DOI: https://doi.org/10.30574/wjbphs.2025.24.1.0860.