Department of Botany, Mar Ivanios College (Autonomous), Nalanchira, Thiruvananthapuram, Kerala, India-695015.
World Journal of Biology Pharmacy and Health Sciences, 2025, 24(02), 100-107
Article DOI: 10.30574/wjbphs.2025.24.2.0768
Received on 15 July 2025; revised on 20 August 2025; accepted on 23 August 2025
Objective: To evaluate fenugreek (FGM) and flaxseed (FXM) mucilages as natural binders for pharmaceutical tablets.
Methods: Mucilage was extracted, characterized (physicochemical, phytochemical, microbial analysis), and used to formulate tablets. Binding efficacy was assessed by testing tablet hardness, friability, and disintegration time against a gelatin standard.
Results: Both mucilages were safe, carbohydrate-rich polymers. Tablets with FGM and FXM disintegrated faster (7:50 and 8:02 minutes, respectively) than gelatin tablets (10:36 minutes), while maintaining adequate mechanical strength.
Conclusion: FGM and FXM are effective, sustainable natural binders that enhance tablet disintegration, offering a eco-friendly alternative to synthetic binders.
Natural Binders; Fenugreek Mucilage; Flaxseed Mucilage; Tablet Disintegration; Green Pharmacy
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Rejitha L R, C Suju Skaria, Lakshmi Jiji and Aswin S K. Evaluation of fenugreek and flaxseed mucilage’s as natural binders in pharmaceutical tablet formulation: a comparative study of physicochemical and tablet properties. World Journal of Biology Pharmacy and Health Sciences, 2025, 24(02), 100-107. Article DOI: https://doi.org/10.30574/wjbphs.2025.24.2.0768.